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Table 2 The clinicopathological characteristics of CC patients with rapid-engraftment (n = 25) and slow- and non-engraftment (n = 44)

From: Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient’s response to conventional and novel therapies

Variable

Rapid-engrafters (n = 25)

Slow- and non- engrafters (n = 44)

p

Median age at surgery, years (IQR)

48

54

0.345

(43–54)

(48–59)

Histology, n (%)

  

0.865

 SC

21 (84.0)

35 (79.6)

 

 AC

3 (12.0)

6 (13.6)

 

 Others

1 (4.0)

3 (6.8)

 

Tumor Stagea, n (%)

 

0.057

 Early

4 (16.0)

17 (38.6)

 

 LACC

10 (40.0)

18 (40.9)

 Advanced

11 (44.0)

9 (20.5)

Tumor differentiation, n (%)

 

0.386

 Poor

11 (44.0)

23 (52.3)

 

 Moderate

14 (56.0)

19 (43.2)

 Well

0 (0.0)

2 (4.5)

Tumor Size, n (%)

  

0.001

 ≥ 4 cm

10 (40.0)

36 (81.8)

 

 < 4 cm

15 (60.0)

8 (18.2)

Tumor Invasion, n (%)

 

0.449

 Superficial

9 (36.0)

12 (27.3)

 

 Deep

16 (64.0)

32 (72.7)

LN metastases, n (%)

 

0.009

 Yes

12 (48.0)

8 (18.2)

 

 No

13 (52.0)

36 (81.8)

LVSI, n (%)

  

0.663

 Yes

11 (44.0)

17 (38.6)

 

 No

14 (56.0)

27 (61.4)

SMI, n (%)

  

0.846

 Yes

3 (12.0)

6 (13.6)

 

 No

22 (88.0)

38 (86.4)

NI, n (%)

  

0.433

 Yes

1 (4.0)

4 (9.1)

 

 No

24 (96.0)

40 (90.9)

PI, n (%)

  

0.097

 Yes

3 (12.0)

1 (2.3)

 

 No

22 (88.0)

43 (97.7)

Prognosis, n (%)

  

0.17

 Non-recurrence

20 (80.0)

37 (84.1)

 

 Recurrence

0 (0)

1 (2.3)

 Death

2 (8.0)

0 (0.0)

 Unknown

3 (12.0)

6 (13.6)

  1. A Diagnosis was made according to the 2018 staging system of the International Federation of Gynecology and Obstetrics
  2. AC adenocarcinoma, LN lymph node, LVSI lymphatic vascular space invasion, NI nerve invasion, NACT neoadjuvant chemotherapy, PI parametrial invasion, SC squamous carcinoma, SMI surgical margin involvement