Table 1 The clinicopathological characteristics of samples used for establishing CC PDXs
Variable | All patients | Engrafters | Non-engrafters | Take rate (%) | p |
|---|---|---|---|---|---|
(n = 69) | (n = 44) | (n = 25) | |||
Median age at surgery, years (IQR) | 52 (47–58) | 51 (45–56) | 55 (50, 60) | 0.907 | |
Histology, n (%) | 0.865 | ||||
SC | 56 (81.1) | 35 (79.6) | 21 (84.0) | 62.5 | |
AC | 9 (13.1) | 6 (13.6) | 3 (12.0) | 66.7 | |
Others | 4 (5.8) | 3 (6.8) | 1 (4.0) | 75 | |
Tumor stagea, n (%) | 0.275 | ||||
Early | 21 (30.4) | 12 (27.3) | 9 (36.0) | 57.1 | |
LACC | 28 (40.6) | 17 (38.6) | 11 (44.0) | 60.7 | |
Advanced | 20 (29.0) | 15 (34.1) | 5 (20.0) | 75 | |
Tumor differentiation, n (%) | 0.915 | ||||
Poor | 34 (49.3) | 22 (50.0) | 12 (48.0) | 64.7 | |
Moderate | 33 (47.8) | 21 (47.7) | 12 (48.0) | 63.6 | |
Well | 2 (2.9) | 1 (2.3) | 1 (4.0) | 50 | |
Tumor size, n (%) | 0.021 | ||||
≥ 4 cm | 46 (66.7) | 25 (56.8) | 21 (84.0) | 54.4 | |
< 4 cm | 23 (33.3) | 19 (43.2) | 4 (16.0) | 82.6 | |
Tumor invasion, n (%) | 0.831 | ||||
Superficial | 21 (30.4) | 13 (29.5) | 8 (32.0) | 61.9 | |
Deep | 48 (69.6) | 31 (70.5) | 17 (68.0) | 64.6 | |
LN metastases, n (%) | 0.215 | ||||
Yes | 20 (29.0) | 15 (34.1) | 5 (20.0) | 75 | |
No | 49 (71.0) | 29 (65.9) | 20 (80.0) | 59.2 | |
LVSI, n (%) | 0.109 | ||||
Yes | 28 (40.6) | 21 (47.1) | 7 (28.0) | 75 | |
No | 41 (59.6) | 23 (52.9) | 18 (72.0) | 56.1 | |
SMI, n (%) | 0.583 | ||||
Yes | 9 (13.1) | 5 (11.4) | 4 (16.0) | 55.6 | |
No | 60 (86.9) | 39 (88.6) | 21 (84.0) | 65 | |
NI, n (%) | 0.097 | ||||
Yes | 5 (7.3) | 5 (11.4) | 0 (0.0) | 100 | |
No | 64 (92.7) | 39 (88.6) | 25 (100.0) | 60.9 | |
PI, n (%) | 0.63 | ||||
Yes | 4 (5.8) | 3 (6.9) | 1 (4.0) | 75 | |
No | 65 (94.2) | 41 (93.1) | 24 (96.0) | 63.1 | |
Prognosis, n (%) | 0.236 | ||||
Non-recurrence | 57 (82.6) | 34 (77.3) | 23 (92.0) | 59.7 | |
Recurrence | 1 (1.4) | 1 (2.3) | 0 (0.0) | 100 | |
Death | 2 (2.9) | 2 (4.5) | 0 (0.0) | 100 | |
Unknown | 9 (13.1) | 7 (15.9) | 2 (8.0) | 77.8 | |
NACT, n (%) | 0.63 | ||||
Yes | 4 (5.8) | 3 (6.9) | 1 (4.0) | 75 | |
No | 65 (94.2) | 41 (93.1) | 24 (96.0) | 63.1 | |