Fig. 4

The overview of tumor immune microenvironment and transcriptome profiles of Engrafters and Non-Engrafters. a The proportion of leukocytes in Engrafters and Non-Engrafters. b The proportion of T, B, and natural killer cells and monocytes in Engrafters and Non-Engrafters. c The proportion of immune cell subsets in Engrafters and Non-Engrafters according to the Cell-type Identification by Estimating Relative Subsets of RNA Transcripts. d Volcano plots illustrating the differentially expressed genes (DEGs) of primary tumors that were successfully engrafted (n = 16) versus those that were not successfully engrafted (n = 10). In total, 564 DEGs (258 upregulated and 306 downregulated) were founded. e, f The gene set enrichment analysis for engrafters versus non-engrafters (blue, downregulated pathways; red, upregulated pathways). The data are represented as the mean ± standard error of the mean. Statistical analyses are performed using the Mann–Whitney U test. ^*p < 0.05