Tumor type | Sample size | TILs evaluation | TILs evaluation method | Imaging modality | Feature selection | Model | Training set performance | Validation set performance | References |
---|---|---|---|---|---|---|---|---|---|
N/A | 254 | CD8+TILs | RNA-seq | CT | Elastic-net | Linear regression | AUC 0.74 | AUC 0.67 | [43] |
UPS | 14 | CD8+TILs | RNA-seq | MRI | N/A | N/A | ACC 93% | N/A | [54] |
TNBC | 139 | TILs | RNA-seq | MRI | Elastic net | LR | AUC 0.868 | AUC 0.790 | [46] |
TNBC | 43 | TILs | IHC | Mammography | Mann–Whitney U-test/PCC | N/A | N/A | N/A | [55] |
TNBC | 80 | TILs | HE | MRI | N/A | N/A | AUC 0.752 | N/A | [51] |
BC | 133 | TILs | HE | MRI | LASSO | LR | AUC 0.934 | AUC 0.872 | [47] |
BC | 172 | TILs | IHC | MRI | LASSO | Linear regression | AUC 0.742 | AUC 0.718 | [56] |
BC | 121 | TILs | HE | Mammography | RFE | LR | AUC 0.83 | AUC 0.79 | [57] |
BC | 154 | TILs | NA | MRI | LASS0 | LR | AUC 0.86 | AUC 0.83 | [58] |
RC | 141 | CD8+TILs | IHC | MRI | LASSO | Linear regression | AUC 0.760 | AUC 0.729 | [42] |
RC | 133 | T cells | IHC | MRI | GBDT | LR | AUC 0.770 | AUC 0.768 | [59] |
CCLM | 103 | T cells | IHC | CT | N/A | SVM | N/A | N/A | [60] |
HGG | 51 | T cells | FCM | MRI | sPLS | sPLS-DA | AUC 0.986 | N/A | [61] |
LGG | 107 | B/T cells | RNA-seq | MRI | LASSO | COX | R correlation coefficient | [62] | |
0.975 (B cell) | 0.429 | ||||||||
0.474 (CD8 T cell) | 0.552 | ||||||||
NSCLC | 100 | TILs | IHC | CT | Mann–Whitney U | Cox model | AUC 0.91 | N/A | [52] |
NSCLC | 103 | CD8+TILs | IHC | PET/CT | LASSO | LR | AUC 0.800 | AUC 0.794 | [63] |
NSCLC | 290 | TILs | IHC | CT | N/A | COX | N/A | N/A | [64] |
NSCLC | 117 | CD8+TILs | IHC | CT | LASSO | N/A | AUC 0.83 | AUC 0.68 | [65] |
NSCLC | 60 | TILs | IHC | CT | PCA | N/A | N/A | N/A | [66] |
NSCLC | 149 | CD8+T cells | RNA-seq | CT | N/A | RF | AUC 0.681 (RF) | N/A | [67] |
LDA | AUC 0.674 (LDA) | ||||||||
CART | AUC 0.647 (CART) | ||||||||
NSCLC | 97 | CD8+TILs | FACS | CT | N/A | Neural network | 0.788 | 0.753 | [68] |
NSCLC | 91 | CD8+TILs | IHC | PET-CT | LASSO | LR | 0.818 | N/A | [69] |
NSCLC | 44 | CD8+TILs | IHC | PET | N/A | COX | 0.9 | N/A | [70] |
NSCLC | 221 | CD8+T cells | IHC | PET/CT | LASSO | LR | 0.907 | 0.883 | [71] |
PDAC | 184 | CD8+TILs | IHC | CT | LASSO | XGBoost | AUC 0.75 | AUC 0.67 | [48] |
PDAC | 156 | CD20B cells | IHC | MRI | LASSO | LR | AUC 0.79 | AUC 0.79 | [72] |
PDAC | 114 | CD8+T cells | IHC | MRI | LASSO | LDA | AUC 0.85 | AUC 0.76 | [73] |
PDAC | 183 | TILs | IHC | CT | NA | XGBoost | AUC 0.93 | AUC 0.79 | [74] |
PDAC | 156 | TILs | IHC | MRI | LASSO | XGBoost | AUC 0.86 | AUC 0.79 | [49] |
HCC | 142 | CD8+T cells | IHC | CT | Elastic-net | linear regression | AUC 0.751 | 0.705 | [50] |
HCC | 207 | T cells | IHC | MRI | Randomized tree | Randomized tree | AUC 0.904 | AUC 0.823 | [75] |
HNSCC | 160 | CD8+T cells | RNA-seq | CT | Consensus clustering | RF | ACC 65.7% | N/A | [76] |
HNSCC | 71 | CD8+T cells | IHC | CT | LASSO | LR | 0.786 | N/A | [77] |
ESCC | 220 | CD8+T cells | IHC | CT | LASSO | LR | 0.764 | 0.728 | [78] |