The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis

Table 1 TCGA cohorts of EAC and GAC

CIN chromosome instability-associated GAC, CLDN6 claudin 6, EAC esophageal adenocarcinoma, EBV EBV-associated GAC, GAC gastric adenocarcinoma, GS Genomic stable GAC, M distant metastasis, median age median age at diagnosis, pT tumor stage, pN lymph node stage, MSI-high microsatellite-instable GAC, NA not available, TCGA The Cancer Genome Atlas
^aMolecular subtype according to the molecular TCGA subtype classification of GAC [29]
^bCLDN6 expression (TPM, RSEM-normalized) dichotomized by the best cutoff value for a significant difference in overall survival in a log-rank test (see methods)

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