Fig. 1

Higher CLDN6 mRNA expression is associated with shorter OS and a poor prognosis. A OS for 89 EAC specimens dichotomized by the median CLDN6 expression (TPM, RSEM-normalized). B OS in EACs dichotomized by the best survival-associated cutoff identified by the Cutoff Finder tool; n > best cutoff = 14, n < best cutoff = 75. C OS in GAC specimens (n = 371) stratified by the median CLDN6 expression; D OS differences in GAC patients, dichotomized by the best survival-associated cutoff identified by the Cutoff Finder tool; n > best cutoff = 68, n < best cutoff = 303. CLDN6 = claudin 6, EAC esophageal adenocarcinoma, GAC gastric adenocarcinoma, OS overall survival, TCGA The Cancer Genome Atlas, TPM transcripts per million. A p-value < 0.05 (log-rank test) was considered significant