Table 1 Clinical characteristics and multi-omics methods of highlighted articles
| Â | Devarakonda et al. [20] | Zhang et al. [22] | Chen et al. [21] |
|---|---|---|---|
Sample size for genomic analysis | 459 | 232 | 103 |
Number of never smokers | 88 (+ 76 NS external samples) | 232 | 85 |
Sample type | Lung tumor, adjacent normal tissue | Lung tumor, adjacent normal tissue, and blood | Lung tumor, adjacent normal tissue, and blood |
NSCLC Type | LUAD (100%) | LUAD (81.5%) Carcinoids (15.5%) Other (3%) | LUAD (100%) |
Mean patient age at diagnosis (SD) | 68.2 (11.8) | 64.8 (11.9) | 63.5 (10.3) |
Patient sex (%) | Male (29.9%) | Male (24.6%) | Male (29.4%) |
Female (70.1%) | Female (75.4%) | Female (70.6%) | |
Never smoker patient ethnicity (%) | Caucasian (72.7%) | European (97%) | Taiwanese (100%) |
Asian (12.5%) | Asian (2%) | ||
African (9.1%) | African (1%) | ||
Other (5.7%) | |||
Methods | Whole exome sequencing | Whole genome sequencing | Whole exome sequencing |
RNA sequencing | |||
RNA sequencing | 35 LUAD underwent RNA-Seq | Proteome analysis | |
Phosphoproteome analysis |