Fig. 1

Androgen-motivated VCaP transcriptomes are coupled to AR direct and indirect dual-functions. A, B Heatmap analyses of androgen-activated versus androgen-repressed transcriptomes of VCaP treated with androgen (Vehicle control versus 10 nM of DHT for 2 h and 10 h, respectively) (GSE157107). C Global AR binding distribution analyses: chromatin affinity and proximity were computed based on VCaP AR ChIP-seq datasets GSE55062. Color denotes: androgen-activated genes (red); androgen-repressed genes (blue); and genomic background (black). D Bioinformatics analysis of androgen-mediated RNA-Seq in combination with MYC ChIP-Seq datasets (GSE157107)