Fig. 4

The characterization of monocytes 3 from MC PBMCs. a. The expression of relevant cytokines and chemokines across all cell types at MC. The eight chemokines were in fact found surging in plasma at the acute stage of MC in our previous follow-up study [15]. The nine chemokines are representative CC (induce migration of lymphocytes and monocytes) and CXC (promote neutrophil migration) chemokines. The monocytes 3 exhibited high expression of IL1B and CXCL8, which potentially might augment the MC inflammation. b. The receptors expression of (IL-1 and CXCL8) in different cells at MC. c. Expression of CXCL8, IL1B, and RNASE2 in different monocytes. d. The inflammasome signaling scores in all cell types. The monocyte 3 exhibited the highest activation in inflammasome signaling at MC. e. The interferon signaling scores in all cell types. The interferon signaling was highest activated in monocytes at MC. f. The cell–cell communications between monocytes 3 and other cell types at MC. g. The B activation (BAFF) signaling communications among all cell types at MC