Fig. 2
Hemogram results and overall differentially expressed genes (DEG) analysis of all PBMCs. a. The DEG analysis of all MC PBMCs (at MC vs. three months after MC). Myeloid cell pathways activation indicated an innate immune activation, while lymphoid cell pathways suppression indicated an adaptive immune inhibition. b. Enrichment analysis of MC up-regulated genes (n = 440) in different databases. The CellMarker enrichment indicates monocytes were the most activated cell type. c. Enrichment analysis of MC down-regulated genes (n = 903) in different databases. The CellMarker enrichment indicates lymphocytes were the most repressed cell types. d. the hemogram results of 22 AChR+ MC patients between the acute stage at MC and three months after MC (Bonferroni adjusted p-values). Extremely neutrophilia and lymphopenia comprise the drastically higher neutrophil–lymphocyte ratio (NLR) at MC. e. The correlation relationships between NLR and MG-related clinical scores (Bonferroni adjusted p-values). Three (ADL, MMT, QMG) of four scores show the positive relationships between NLR and clinical severity. QMG, Myasthenia Gravis Foundation of America quantitative myasthenia gravis score; MMT, MG-specific manual muscle testing; ADL, Myasthenia Gravis Activities of Daily Living Scale; QOL-15, Myasthenia Gravis quality of life questionnaire