Fig. 1
From: GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer
Expression of GPRC5D in NSCLC and its predictive value for immunotherapy. A Expression atlas of GPRC5D in pan-cancer. The data was obtained from the TCGA dataset. B Expression of GPRC5D in EGFR-mutant, EGFR-wild/immuno-hot, and EGFR-wild/immuno-cold tumors. The data was obtained from the TCGA dataset. C Correlation between GPRC5D expression and T cell inflamed score. The data was obtained from the TCGA dataset. D Representative images showing GPRC5D expression in EGFR-WT and immuno-hot and EGFR-WT and immuno-cold NSCLC groups, along with semi-quantitative analysis. Total original magnification, ×200. E The tSNE plot displaying the main cell types in the scRNA-seq dataset. F Distribution of GPRC5D-positive cells. G Expression of GPRC5D in tumor and non-tumor region. H Expression of GPRC5D in tumors from responders and non-responders and ROC analysis. The data was obtained from the GSE126044 dataset. I Representative images showing GPRC5D expression in tumors from responders and non-responders in the in-house cohort, along with semi-quantitative analysis. Total original magnification, ×200