Fig. 1

Treatment with HBO modulate the development of chronic pain after SNC. A The experimental timeline. Mechanical and thermal sensitivity, and motor performance were measured Pre-SNC and Post-SNC. After SNC animals were randomly assigned to one of the experiment group: SNC group, SNC-HBOT group. The HBO treatment was performed after 4h of the SNC, and twice a day to day 7 after SNC. Locomotion and motor performance tests were performed on day 9 to 11 after SNC. B Mechanical force withdrawal (G) of the ipsilateral and contralateral side of the SNC and the SNC^(HBOT) group. C Sum of nociceptive response in the hot plate test before and after SNC. D Motor performance in rotarod test expressed by latency to fall (Second). E Motor improvement between sessions in rotarod test expressed by latency to fall. F Distance moved in the OF test (cm). G Velocity (cm/s) in the OF test. Behavioral assessment (n = 10–13 per group). Mixed Model ANOVA-Followed with Student t-test; Parried sample t-test; Student t-test. Mean ± SEM. ^#P < 0.05, ^###P < 0.001 Difference between groups; ^***P < 0.001 Compared to Baseline/Time-point comparison