Fig. 5

The effects of JorA on the transcription level of MIBC cells. A The diagram of transcriptomics library construction. B Principal component analysis of control group (CTL) and JorA treatment group (JAT). C Volcanic map of transcripts whose expression levels are significantly affected by JorA. Gray dots refer to genes with no significant difference; red dots refer to upregulated genes with significant differences, and blue dots refer to downregulated genes with significant differences. D Left: The relationship between the KLHDC7B expression level and the survival rate of bladder cancer patients; Right: The differential expression of KLHDC7B in bladder tumor tissues and normal bladder tissues. Data are obtained from GEPIA (http://gepia.cancer-pku.cn/). E The differential expression of RNF116 and NKD1 in bladder tumor tissues and normal bladder tissues. Data are obtained from GEPIA. F Top 30 pathways in GO enrichment analysis of JorA-induced significantly changed genes. G The transcription factors of gene with significant changes caused by JorA are displayed in pie chart