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Table 3 The association between BMI trajectories and osteoporosis/osteopenia of different skeletal sites

From: BMI trajectory of rapid and excessive weight gain during adulthood is associated with bone loss: a cross-sectional study from NHANES 2005–2018

Stable

Osteoporosis

Osteopenia

Model 1

P-value

Model 2

P-value

Model 3

P-value

Model 1

P-value

Model 2

P-value

Model 3

P-value

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Femur neck

 Slight increase

1.21 (0.70,2.08)

0.497

1.06 (0.61,1.85)

0.839

1.13 (0.66,1.94)

0.645

1.11 (0.89,1.38)

0.346

1.10 (0.89,1.36)

0.393

1.21 (0.95,1.52)

0.116

 Increase to decrease

1.02 (0.28,3.73)

0.975

0.85 (0.23,3.13)

0.812

0.99 (0.27,3.58)

0.985

0.77 (0.44,1.33)

0.345

0.73 (0.41,1.30)

0.279

0.72 (0.44,1.15)

0.169

 Rapid increase

1.09 (0.15,7.89)

0.933

0.83 (0.11,6.42)

0.862

0.90 (0.12,6.99)

0.922

1.32 (0.93,1.88)

0.126

1.35 (0.94,1.94)

0.105

1.45 (1.00,2.09)

0.048

Lumbar spine

 Slight increase

0.90 (0.59,1.37)

0.615

0.78 (0.49,1.23)

0.282

0.90 (0.56,1.45)

0.660

0.96 (0.71,1.30)

0.811

0.93 (0.69,1.25)

0.632

1.00 (0.73,1.38)

0.978

 Increase to decrease

0.73 (0.27,1.95)

0.531

0.57 (0.19,1.67)

0.305

0.74 (0.25,2.19)

0.593

1.00 (0.55,1.80)

0.988

0.99 (0.53,1.86)

0.984

0.96 (0.59,1.57)

0.881

 Rapid increase

2.16 (1.13,4.10)

0.019

1.97 (1.00,3.88)

0.049

2.11 (1.06,4.20)

0.034

1.50 (0.99,2.28)

0.056

1.52 (0.98,2.36)

0.063

1.66 (1.05,2.63)

0.029

  1. Model 1: adjusted for age, sex, ethnicity, and baseline BMI
  2. Model 2: model 1 plus education, smoking, alcohol drinking, physical activity, and sleep status
  3. Model 3: model 2 plus cancer, diabetes, and total cholesterol
  4. P-values < 0.05 were indicated in bold
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Journal of Translational Medicine

ISSN: 1479-5876

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