Fig. 7

LIGHT promoted BMDM M2 polarization in which PI3Kγ and SGK1 activation are indispensable. a Representative morphological images of BMDMs from the different groups. b Supernatant protein levels of TNF-α, IL-1β, TGF-β1, and IL-10 in different groups. c mRNA levels of IL-10, TGF-β1, ARG1, and CD163 in different groups. d Western blot images of SGK1, AKT, phospho-AKT, PI3Kγ, ARG1, CD163, CD206, and TGF-β1, and e relative expression in the different groups. f Representative fluorescent images of CD163 and the relative fluorescence intensity in different groups. g Representative FCM images and the proportion of CD206-positive macrophages in different groups. *p < 0.05, **p < 0.01. IPI: a PI3Kγ inhibitor, IPI549; GSK: a SGK1 inhibitor, GSK650394