Fig. 4

Upregulation of UCP1 and CL316243 treatment inhibits EMT and ECM accumulation in vitro. A Representative images and B corresponding quantification of UCP1 in HK2 cells in different cell groups. C Representative images and D corresponding quantification of UCP1 in HK2 cells in different cell groups. E Representative images and F corresponding quantification of Fibronectin, Collagen I, E-cadherin and α-SMA in HK2 cells in different cell groups. G Representative images and H corresponding quantification of Fibronectin, Molecular Collegen I, E-cadherin and α-SMA in HK2 cells in different cell groups. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. Ctrl; # vs. TGF-β1