Fig. 1

Diagram of the mechanism of MAFLD/NASH occurrence, and the various metabolic problems that occur along with it. High calorie foods, and the ab initio synthesis of fats lead to the production of large amounts of free fatty acids in the liver, which, together with excess total cholesterol, leads to insulin resistance in the body. High levels of free fatty acids can lead to a range of problems in the body such as polycystic ovary syndrome, oxidative stress, inflammation, apoptosis, pyroptosis and a decrease in mitochondrial membrane potential, ultimately leading to the development of NAFLD/MAFLD in the body