Fig. 7

IL11 as the hub gene used for cell type enrichment analysis and expression analysis. A Correlation analysis among IL11 and 64 immune and stroma cell types in renal papillary Randall’s plaque (RP) and normal papillary tissue. B IL11 over-expression in tubulointerstitium vs. glomeruli tissue of the normal adult human kidney explored in the Nephroseq database. C IL11 over-expression in papillary tips vs. all other tissues of the normal adult human kidney explored in the Nephroseq database. D IL11 over-expression in chronic kidney disease vs. normal kidney explored in the Nephroseq database. E IL11 expression correlated with GFR in healthy living donors explored in the –Nephroseq database. F IL11 expression correlated with serum creatinine in open donor nephrectomy samples explored in the Nephroseq database. G Expression profiles of IL11 in kidney cell types based on the HPA database. H Heatmap for the expression of IL11 and recognized cell type markers across distinct single cell type clusters of the kidney based on HPA database