Fig. 4

Enrichment analysis of shared genes from kidney stones with diabetes. A AWFE sets of the shared genes between the MEyellow module of kidney stones and MEturquoise, MEblue, MEpurple, MEred, MEcyan modules of diabetic by overlapping them. B Chow-Ruskey diagrams of 17 common genes identified from the intersection of DEGs in kindey stones using Limma and the shared genes between kidney stones and diabetic using WGCNA. Color of the borders around each intersection corresponds to the modules whose genes overlap. The green circle in the middle represents the overlap of all modules. Lighter shades of brown, blue and pink represent the overlap of fewer modules. Area of each intersection is proportional to number of genes within the intersection. C Circos track plot used to map the location of 11 shared genes on the chromosomes. D Circos plot demonstrating the interconnectivity among 11 shared genes. The hue and width of the ribbons are associated with the expression levels of genes, with red signifying a positive relationship and green indicating a negative one. E Matrix graphs of correlation analysis of 11 shared genes. F PPI network for the obtained 11 common genes constructed by GeneMANIA. G GO enrichment analysis of the obtained 11 common genes. H KEGG and Reactome enrichment analysis of the obtained 11 common genes