Table 3 Hazard Ratios and 95% CIs of Incident Colorectal Cancer in the PLCO Cohort, by Quartiles of Paleolithic Diet score

Colorectal cancer^b

 Cases

200

148

179

167

NA

 Person-years

157688

136768

193197

199074

NA

 Incidence rate (95% CI)^c

1.27 (1.10, 1.46)

1.08 (0.92, 1.27)

0.93 (0.8, 1.07)

0.84 (0.72, 0.98)

NA

 Unadjusted

1.00 (reference)

0.85 (0.69, 1.06)

0.73 (0.6, 0.89)

0.66 (0.54, 0.81)

 < 0.001

 Model 1^d

1.00 (reference)

0.87 (0.71, 1.08)

0.77 (0.62, 0.94)

0.72 (0.58, 0.90)

0.002

 Model 2^e

1.00 (reference)

0.88 (0.71, 1.09)

0.79 (0.64, 0.97)

0.76 (0.61, 0.95)

0.009

Proximal colon cancer

 Cases

117

94

109

100

NA

 Incidence rate (95% CI) ^c

0.74 (0.62, 0.89)

0.69 (0.56, 0.84)

0.56 (0.47, 0.68)

0.50 (0.41, 0.61)

NA

 Unadjusted

1.00 (reference)

0.93 (0.71, 1.21)

0.76 (0.59, 0.99)

0.68 (0.52, 0.88)

0.002

 Model 1^d

1.00 (reference)

0.93 (0.71, 1.22)

0.77 (0.59, 1.00)

0.70 (0.52, 0.92)

0.006

 Model 2^e

1.00 (reference)

0.94 (0.71, 1.23)

0.78 (0.60, 1.02)

0.73 (0.55, 0.97)

0.02

Distal CRC

 Cases

82

54

69

67

NA

 Incidence rate (95% CI)^c

0.52 (0.42, 0.65)

0.39 (0.30, 0.52)

0.36 (0.28, 0.45)

0.34 (0.27, 0.43)

NA

 Unadjusted

1.00 (reference)

0.76 (0.54, 1.07)

0.69 (0.50, 0.95)

0.65 (0.47, 0.89)

0.008

 Model 1^d

1.00 (reference)

0.80 (0.57, 1.13)

0.77 (0.55, 1.06)

0.78 (0.55, 1.10)

0.15

 Model 2^e

1.00 (reference)

0.81 (0.58, 1.15)

0.79 (0.57, 1.09)

0.82 (0.58, 1.16)

0.25