Fig. 4

GAA suppresses OXPHOS in OC by targeting LRPPRC. A Heatmap showing changes in protein expression after GAA treatment. B KEGG analysis of genes significantly altered by GAA compared to control A2780 cells. C, D Western blot of LRPPRC protein levels in ovarian cancer cells following GAA treatment. E–H Examination of GAA-LRPPRC binding in A2780 and SKOV3 cells using cellular thermal shift and western blot assays. I–K Predicted binding mode of GAA to LRPPRC via docking analysis. L CCK8 detection of cell survival rates in GAA-treated A2780 cells with LRPPRC knockdowns