Table 2 Exosomal circRNAs in body fluids for cancer diagnosis
From: Recent advances of exosomal circRNAs in cancer and their potential clinical applications
Cancer | circRNAs | Level | Function | References |
|---|---|---|---|---|
CRC | Circ-LPAR1 | Down | Diagnostic biomarker (AUC 0.875) | [55] |
CRC | Circ-GAPVD1 | Up | Diagnostic biomarker (AUC 0.7662) | [168] |
CRC | Circ-HIPK3 | Up | Diagnostic biomarker (AUC 0.771) | [169] |
CRC | Circ-PNN | Up | Early-stage diagnosis (AUC 0.854) | [170] |
GC | Circ_0015286 | Up | Diagnostic biomarker | [166] |
GC | Circ_0000437 | Up | Associated with LNM | [167] |
GC | Circ-CDR1as | Up | Diagnostic biomarker (AUC 0.536) | [171] |
GC | Circ_0065149 | Down | Early diagnosis and prognosis prediction (AUC 0.64) | [172] |
GC | Circ-KIA1244 | Down | TNM stage and lymphatic metastasis (AUC 0.7481) | [173] |
GC | Circ_0000419 | Down | Diagnostic biomarker (AUC 0.84) | [174] |
BC | Circ-MMP11 | Up | Diagnostic biomarker (AUC 0.9444) | [117] |
BC | Circ-HIF1A | Up | Diagnostic biomarker (AUC 0.897) | [175] |
BC | Circ_0000615 | Up | Diagnostic biomarker (AUC 0.904) | [176] |
NSCLC | Circ_0047921, Circ_0056285, Circ_0007761 | - | Diagnostic biomarker in the Chinese population (AUC 0.89, 0.820) | [177] |
NSCLC | Circ_0048856 | Up | Diagnostic biomarker (AUC 0.943) | [178] |
NSCLC | Circ_0069313 | Up | Diagnostic biomarker (AUC 0.749) | [179] |
NSCLC | Circ-ERBB2IP | Up | Positively correlated with malignant (AUC 0.9168) | [180] |
LUAD | Circ_0001492, Circ_0001439, Circ_0000896 | Up | Diagnostic biomarker (AUC 0.805) | [164] |
LUAD | Circ_0056616 | Up | Biomarker for lymph node metastasis (AUC 0.812) | [181] |
LUAD | Circ_0013958 | Up | TNM stage and lymphatic metastasis (AUC 0.815) | [182] |
LUSC | Circ_0014235, Circ_0025580 | Up | Diagnostic biomarker (AUC 0.8) | [183] |
Lung cancer | Circ_0002490, Circ_0087357, Circ_0004891, Circ_0074368 | Down | Diagnostic biomarker (AUC 0.833, 0.793, 0.773, 0.730) | [184] |
HCC | Circ_0051443 | Down | Diagnostic biomarker (AUC 0.8089) | [57] |
HCC | Circ_0028861 | Down | Diagnostic biomarker | [165] |
HCC | Circ-SMARCA5 | Down | Diagnostic biomarker (AUC 0.862) | [185] |
HCC | Circ_0006602 | Up | Diagnostic biomarker (AUC 0.907) | [186] |
HCC | Circ_0004001, Circ_0004123, Circ_0075792 | – | Positively correlated with the TNM stage and tumor size | [187] |
ESCC | Circ_0026611 | Up | Lymph node-metastatic biomarker (AUC 0.724) | [188] |
ESCC | Circ_0001946 | Up | Predict the recurrence and prognosis (AUC 0.894) | [189] |
MM | Circ-MYC | Up | Recurrence and Bortezomib resistance (AUC 0.924) | [190] |
Ovarian | Circ_0001068 | Up | Diagnostic biomarker (AUC 0.9697) | [146] |
AC | Circ_0109049 Circ_0002577 | Up | Diagnostic stage III biomarker | [159] |
OSCC | Circ_047733 | Down | Negatively with LNM | [161] |
GBM | Circ_0055202, Circ_0074920, Circ_0043722 | Up | Predict the tumor progression | [162] |
PCa | Circ_0006220 Circ_0001666 | Up | Diagnostic biomarker (AUC 0.884) | [163] |