Fig. 5

PKM2 is essential for ESRRG to inhibits tumor growth in ESCC cells. A–D Cell growth were determined in ESRRG knockdown ECa109 and KYSE510 cells with or without further knockdown of PKM employing CCK-8 assays(A, colony formation B and EDU assay (C, D). E Typical pictures of tumors isolated from nude mice with tumor xenografts derived from the indicated groups. F Tumour volumes were monitored at indicated time points. G The weight of tumours was measured at time of sacrificed. Values are presented as mean ± SD (n = 3–5). *P < 0.05 or **P < 0.01 indicates significant differences from the vehicle group as assessed by a one-way ANOVA with a post hoc Dunnett’s test