Fig. 3

ESRRG inhibits ESCC progression by regulating Warburg effect. A–D Effects of ESRRG on oxygen consumption ratio (OCR) and extracellular acid ratio (ECAR) in ESCC cells. ATP production, lactate production, pyruvate production and glucose consumption in TE1 cells with ESRRG overexpression E and ECa109 cells with ESRRG knockdown G compared to relative control cells. F Effects of 2-DG on the DNA synthesis of TE1 and ECa109 cells. Values are presented as mean ± SD (n = 3). *P < 0.05 or **P < 0.01 indicates significant differences from the vehicle group as assessed by a one-way ANOVA with a post hoc Dunnett’s test