Fig. 1

Downregulation of ESRRG and prognostic significance in ESCC. A ESRRG expression in paired samples of tumor tissues and nontumorous adjacent normal esophagus tissues from patients with esophageal squamous cell carcinoma (ESCC) in the TCGA and three GSE cohorts. B, C mRNA levels of ESRRG were evaluated using quantitative real-time PCR in 94 paired samples from patients with ESCC. D 8 paired samples from patients with ESCC were analyzed by Western blot. E Immunohistochemical staining for ESRRG was performed from patients with ESCC. F The correlation between the IHC score of ESRRG and the level of tumor cell differentiation in 94 ESCC tissues. G Univariable analyses were conducted in the ESCC cohort, where all bars were corresponded to 95% CIs. H Kaplan–Meier analysis for OS was performed according to ESRRG mRNA levels. *P < 0.05 or **P < 0.01 indicates significant differences from the normal group as assessed by Wilcox test