Fig. 2

sEVs-derived TDRKH-AS1 as a potentially causative factors in PE. A The relative expression of DEGs across sEVs derived from AOPPs-treated trophoblast cells and control group. B The volcano plot shows the up-regulated lncRNAs (red) and down-regulated lncRNAs. C Boxplot of TDRKH-AS1 expression levels in sEVs sequencing. CPM: counts per million. D The enriched KEGG pathways of DEGs in sEVs sequencing. E The relative expression level of TDRKH-AS1 verified by qRT-PCR in sEVs secreted by AOPPs-treated trophoblast cells and control group. F The expression level of TDRKH-AS1 is up-regulated in plasmatic sEVs from EOSPE or LOSPE patients compared with normal group. G The TDRKH-AS1 expression levels in EOSPE or LOSPE placentae compared with normal placentae. H Positive correlation between systolic blood pressure and the relative expression of TDRKH-AS1 in plasmatic sEVs (r = 0.4177, p < 0.001). Positive correlation between diastolic blood pressure and the relative expression of TDRKH-AS1 in plasmatic sEVs (r = 0.5288, p < 0.001). The data are represented as the mean ± SD; **p < 0.01, *p < 0.05