Fig. 7
Effects of SIRT1 activation or inhibition on Fgr -mediated protection against oxidative damage and mitochondrial injury. A Mitochondrial morphology stained by MitoTracker Deep Red probe (n = 5, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, ***p < 0.001, ****p < 0.0001). B, C Mitochondrial membrane potential assayed by JC-1 staining in HT22 cells and statistical analysis (n = 5, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, **p < 0.01, ****p < 0.0001). D, E Representative image and statistical analysis of ROS production in HT22 cells stained with DCFH-DA (green) (n = 6, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, ****p < 0.0001). F–H Relative ATP content (F), MDA content (G), and SOD activity (H) in HT22 cells (n = 3, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, **p < 0.01, ***p < 0.001)