Fig. 5

Effects of Fgr inhibitor on hippocampal activation of SIRT1, PGC-1α, and DRP1 pathways in CLP-induced septic mice. A Representative Western blot of SIRT1, PGC-1α, and DRP1. B–D Statistical analysis of SIRT1, PGC-1α, and DRP1 protein levels (n = 3 mice, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, **p < 0.01, ***p < 0.001). E–G Representative fluorescent images and quantitative analysis of SIRT1, PGC-1α, and DRP1 in the neuron (labeled with NeuN) (n = 5 per group, 3–4 slices per mouse, scale bar = 20 μm, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, **p < 0.01, ***p < 0.001, ****p < 0.0001)