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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway

Fig. 3

Fgr inhibition diminished microglial activation and neuroinflammation. A Representative image of Iba1 (red) and DAPI (blue) fluorescence in the hippocampus at different magnifications (scale bar, 50 μm or 20 μm). B, C Quantitative analysis of Iba1-positive cell number and soma area (n = 5 or 6 mice, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). D, E Levels of IL-6 (D) and TNF-α (E) in the hippocampus (n = 6, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, ****p < 0.0001)

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Journal of Translational Medicine

ISSN: 1479-5876

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