Fig. 2

Fgr inhibition ameliorated the survival rate and cognitive and emotional dysfunction of CLP-induced septic mice. A The survival rate of sham and septic mice treated with Fgr inhibitor TL02-59 (0 [NS], 1, 10, and 15 mg/kg) was recorded at 7 days. B, C Total distance and time spent in center areas during 5-min locomotor activity test in the OFT (n = 8–10, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, ****p < 0.0001). D In the NORT, the recognition index of sham and TL02-59 treated septic mice (n = 8–10, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, **p < 0.01, ***p < 0.001, ****p < 0.0001). E, F In the EPM, time spent in open arms and entries of open arms (n = 8–10, mean ± SEM, one-way ANOVA with Bonferroni post hoc test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)