Fig. 3

Elusive and complicated mechanism of SCLC pathogenesis. Frequently aberrant genes, dysregulated developmental pathways, receptor tyrosine kinase pathways and DNA repair pathways have been detected in SCLC. Targets associated with these pathways, such as IGF-1R, c-MET, VEGF, DLL3, TROP-2, CD-56, ATR, WEE1, CHK1, PARP1 have been proposed in SCLC. Other possible targets associated with metabolism have been also suggested