Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance

Table 2 Biochemical characteristics of the study population

	Lean	OBIR-	EP-OBIR +	LP-OBIR +
Blood glucose curve (mg/dL)
0 min	84.07 ± 0.77	83.19 ± 0.62	86.59 ± 1.56	85.13 ± 1.46
30 min		140.43 ± 6.35	146.50 ± 3.53	134.60 ± 7.23
60 min		116.30 ± 3.69	129.87 ± 3.87^b	129.55 ± 4.06^b
90 min		105.78 ± 2.11	119.13 ± 2.65^b	130.52 ± 4.50^b
120 min		104.23 ± 2.57	120.05 ± 2.33^b	133.85 ± 2.95^a,b
Blood insulin curve (µUI/mL)
0 min	5.42 ± 0.36	11.45 ± 0.53^*	21.32 ± 1.41^*,b	21.00 ± 1.48^*,b
30 min		60.33 ± 5.58	162.39 ± 10.72^b	97.33 ± 6.02^a,b
60 min		67.57 ± 5.28	121.84 ± 8.71^b	91.65 ± 6.71^a,b
90 min		56.97 ± 4.08	99.06 ± 8.17^b	114.48 ± 7.76^b
120 min		43.62 ± 3.11	116.61 ± 1.99^b	137.11 ± 6.66^a,b
HOMA-IR (A.U.)	1.09 ± 0.07	2.43 ± 0.10^*	4.09 ± 0.30^*,b	4.47 ± 0.35^*,b
Mean glucose (mg/dL)		105.38 ± 1.92	118.13 ± 2.57^b	120.58 ± 2.72^b
Mean insulin (µUI/mL)		48.88 ± 2.46	111.80 ± 7.39^b	123.40 ± 9.38^b
AUCg (mg·h/dL)		198.76 ± 8.20	231.52 ± 9.69^b	230.81 ± 7.99^b
AUCi (µU·h/mL)		106.78 ± 6.75	257.46 ± 14.56^b	198.24 ± 10.73^a,b
Total Cholesterol (mg/dL)	173.48 ± 4.74	157.95 ± 3.46^*	157.71 ± 5.35	148.54 ± 3.26^*
Triglycerides (mg/dL)	45.38 ± 2.17	64.15 ± 3.24^*	65.14 ± 5.49^*	70.68 ± 2.44^*
HDL-C (mg/dL)	60.65 ± 1.42	46.26 ± 0.83^*	44.00 ± 0.78^*	41.88 ± 1.26^*,b
LDL-C (mg/dL)	98.29 ± 2.84	96.11 ± 3.01	95.08 ± 4.58	87.33 ± 2.73^*,b
Castelli Index (A.U.)	2.78 ± 0.10	3.32 ± 0.10^*	3.38 ± 0.12^*	3.55 ± 0.13^*
GOT (U/L)	25.88 ± 0.53	22.29 ± 0.76^*	19.19 ± 0.44^*,b	21.00 ± 0.56^*,a
GPT (U/L)	16.29 ± 0.73	17.89 ± 0.66	21.05 ± 1.21^*	19.91 ± 0.92^*

Values are shown as the mean ± SEM. (*) indicates difference with respect to lean children, (b) indicates difference with respect to OBIR- children, and (a) indicates difference with respect to EP-OBIR + children
ObIR-, non-insulin resistant children with obesity; ObIR + , insulin resistant children with obesity; EP-OBIR + , early peak OBIR + children; LP-OBIR + , late peak OBIR + children; HOMA-IR, homeostasis model assessment of insulin resistance; A.U., arbitrary units; AUCg, area under the curve of glucose; AUCi, area under the curve of insulin; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; GOT, aspartate transaminase; GPT, alanine transaminase

ISSN: 1479-5876