Table 4 MR results of causal links between gut microbiome and CRC risk (P < 5 × 10–8)
Data source | Classification | Nsnp | Methods | OR (95% CI) | P-value | Heterogeneity | Horizontal pleiotropy | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
I2 (%) | Cochran’s Q | P-value | Egger intercept | SE | P-value | MR-PRESSO global test p | |||||||
MiBioGen consortium | Total | Â | 12 | Inverse variance weighted (fixed effects) | 1.01 (0.88, 1.15) | 0.906175 | 0 | 9.420471 | 0.571954 | 0.02709012 | 0.029626 | 0.38202 | 0.604 |
| Â | Â | Â | Â | Inverse variance weighted (multiplicative random effects) | 1.01 (0.89, 1.14) | 0.898653 | Â | Â | Â | Â | Â | Â | Â |
| Â | Â | Â | Â | Weighted median | 0.96 (0.79, 1.16) | 0.64935 | Â | Â | Â | Â | Â | Â | Â |
| Â | Â | Â | Â | MR Egger | 0.79 (0.46, 1.35) | 0.412427 | Â | Â | Â | Â | Â | Â | Â |
| Â | Â | Â | Â | Simple median | 1.12 (0.93, 1.35) | 0.228353 | Â | Â | Â | Â | Â | Â | Â |
MiBioGen consortium | Family | Peptostreptococcaceae | 1 | Wald ratio | 4.74 (0.81, 27.82) | 0.085157 | – | – | – | – | – | – | – |
MiBioGen consortium | Genus | Oxalobacter.id | 1 | Wald ratio | 0.81 (0.60, 1.11) | 0.198543 | – | – | – | – | – | – | – |
|  |  | Enterorhabdus.id | 1 | Wald ratio | 1.11 (0.74, 1.66) | 0.617075 | – | – | – | – | – | – | – |
|  |  | Erysipelatoclostridium | 1 | Wald ratio | 1.20 (0.73, 1.99) | 0.4751 | – | – | – | – | – | – | – |
|  |  | RuminococcaceaeUCG009 | 1 | Wald ratio | 1.36 (0.87, 2.12) | 0.1755 | – | – | – | – | – | – | – |
|  |  | Bifidobacterium | 1 | Wald ratio | 0.88 (0.59, 1.33) | 0.5427 | – | – | – | – | – | – | – |
|  |  | RuminococcaceaeUCG013 | 1 | Wald ratio | 1.29 (0.41, 4.13) | 0.6629 | – | – | – | – | – | – | – |
|  |  | Tyzzerella3 | 1 | Wald ratio | 0.92 (0.63, 1.34) | 0.6599 | – | – | – | – | – | – | – |
|  |  | Allisonella | 1 | Wald ratio | 0.9 (0.54, 1.5) | 0.6729 | – | – | – | – | – | – | – |
MiBioGen consortium | Order | Bifidobacteriales | 1 | Wald ratio | 0.88 (0.58, 1.33) | 0.5427 | – | – | – | – | – | – | – |
MiBioGen consortium | Species | Eubacteriumcoprostanoligenesgroup | 1 | Wald ratio | 0.8 (0.44, 1.46) | 0.4634 | – | – | – | – | – | – | – |