Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization

Table 3 Evaluation of heterogeneity and directional pleiotropy using different methods

Data source	Classification	Bacterial taxas	Heterogeneity			Horizontal pleiotropy
Data source	Classification	Bacterial taxas	I² (%)	Cochran’s Q	P-value	Egger intercept	SE	P-value	MR-PRESSO global test p
MiBioGen consortium	Family	Porphyromonadaceae.id.943	8	10.89	0.37	0.00	0.02	0.94	0.5
MiBioGen consortium	Genus	Anaerotruncus.id.2054	0	5.33	0.80	0.01	0.02	0.76	0.797
MiBioGen consortium	Genus	Intestinibacter.id.11345	0	5.17	0.82	0.02	0.03	0.59	0.844
MiBioGen consortium	Genus	RuminococcaceaeUCG004.id.11362	0	5.31	0.72	− 0.04	0.05	0.44	0.779
MiBioGen consortium	Genus	Slackia.id.825	39	13.13	0.11	0.07	0.05	0.20	0.134
MiBioGen consortium	Species	Eubacteriumcoprostanoligenesgroup.id.11375	0	10.88	0.54	0.03	0.03	0.47	0.571
FinnGen	Family	Porphyromonadaceae.id.943	0	6.64	0.76	0.00	0.03	0.99	0.80
FinnGen	Genus	Anaerotruncus.id.2054	45	16.28	0.06	− 0.03	0.05	0.60	0.07
FinnGen	Genus	Intestinibacter.id.11345	2	9.22	0.42	− 0.04	0.05	0.46	0.45
FinnGen	Genus	RuminococcaceaeUCG004.id.11362	8	8.73	0.37	0.01	0.06	0.89	0.40
FinnGen	Genus	Slackia.id.825	0	3.41	0.91	0.07	0.06	0.28	0.92
FinnGen	Species	Eubacteriumcoprostanoligenesgroup.id.11375	0	5.51	0.90	− 0.01	0.04	0.91	0.90

ISSN: 1479-5876