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Table 2 MR results of causal links between gut microbiome and CRC risk (P < 1 × 10–5)

From: Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization

Data source

Classification

Nsnp

Methods

OR (95% CI)

P-value

MiBioGen consortium

Family

Porphyromonadaceae.id.943

11

Inverse variance weighted (fixed effects)

1.26 (1.03, 1.55)

0.0267

    

Inverse variance weighted (multiplicative random effects)

1.26 (1.02, 1.56)

0.0337

    

Weighted median

1.25 (0.93, 1.67)

0.1337

    

MR Egger

1.28 (0.83, 1.96)

0.2923

    

Simple median

1.4 (0.94, 2.08)

0.1003

MiBioGen consortium

Genus

Anaerotruncus.id.2054

10

Inverse variance weighted (fixed effects)

1.17 (0.96, 1.42)

0.1121

    

Inverse variance weighted (multiplicative random effects)

1.17 (1.01, 1.36)

0.0390

    

Weighted median

1.14 (0.88, 1.49)

0.3184

    

MR Egger

1.08 (0.63, 1.85)

0.7807

    

Simple median

1.15 (0.87, 1.51)

0.3265

MiBioGen consortium

Intestinibacter.id.11345

10

Inverse variance weighted (fixed effects)

1.31 (1.09, 1.57)

0.0038

    

Inverse variance weighted (multiplicative random effects)

1.31 (1.14, 1.5)

0.0001

    

Weighted median

1.28 (1, 1.64)

0.0520

    

MR Egger

1.06 (0.5, 2.26)

0.8849

    

Simple median

1.39 (1.08, 1.78)

0.0093

MiBioGen consortium

Slackia.id.825

9

Inverse variance weighted (fixed effects)

1.24 (1.06, 1.45)

0.0071

    

Inverse variance weighted (multiplicative random effects)

1.24 (1.01, 1.51)

0.0357

    

Weighted median

1.15 (0.91, 1.44)

0.2363

    

MR Egger

0.62 (0.24, 1.64)

0.3692

    

Simple median

1.14 (0.88, 1.48)

0.3161

MiBioGen consortium

RuminococcaceaeUCG004.id.11362

9

Inverse variance weighted (fixed effects)

1.27 (1.03, 1.57)

0.0232

    

Inverse variance weighted (multiplicative random effects)

1.27 (1.07, 1.51)

0.0053

    

Weighted median

1.30 (0.99, 1.71)

0.0580

    

MR Egger

2.09 (0.62, 7.13)

0.2754

    

Simple median

1.32 (0.99, 1.74)

0.0563

MiBioGen consortium

Eubacteriumcoprostanoligenesgroup.id.11375

12

Inverse variance weighted (fixed effects)

1.25 (0.99, 1.58)

0.0583

    

Inverse variance weighted (multiplicative random effects)

1.25 (1.00, 1.56)

0.0467

    

Weighted median

1.28 (0.92, 1.79)

0.1387

    

MR Egger

0.86 (0.31, 2.38)

0.7746

    

Simple median

1.62 (1.14, 2.30)

0.0073

FinnGen

Family

Porphyromonadaceae.id.943

11

Inverse variance weighted (fixed effects)

1.50 (1.11, 2.03)

0.0079

    

Inverse variance weighted (multiplicative random effects)

1.50 (1.18, 1.92)

0.0011

    

Weighted median

1.44 (0.95, 2.2)

0.0892

    

MR Egger

1.51 (0.7, 3.23)

0.3177

    

Simple median

1.42 (0.93, 2.17)

0.1062

FinnGen

Genus

Anaerotruncus.id.2054

10

Inverse variance weighted (fixed effects)

1.12 (0.81, 1.55)

0.4987

    

Inverse variance weighted (multiplicative random effects)

1.12 (0.72, 1.73)

0.6149

    

Weighted median

0.91 (0.56, 1.49)

0.7151

    

MR Egger

1.64 (0.38, 7.03)

0.5247

    

Simple median

0.89 (0.55, 1.45)

0.6506

FinnGen

 

Intestinibacter.id.11345

10

Inverse variance weighted (fixed effects)

1.30 (0.99, 1.71)

0.0610

    

Inverse variance weighted (multiplicative random effects)

1.30 (0.98, 1.72)

0.0641

    

Weighted median

1.27 (0.86, 1.88)

0.2207

    

MR Egger

2.12 (0.6, 7.54)

0.2790

    

Simple median

1.35 (0.93, 1.97)

0.1110

FinnGen

 

Slackia.id.825

9

Inverse variance weighted (fixed effects)

1.17 (0.94, 1.46)

0.1557

    

Inverse variance weighted (multiplicative random effects)

1.17 (1.02, 1.36)

0.0298

    

Weighted median

1.24 (0.94, 1.64)

0.1302

    

MR Egger

0.56 (0.16, 1.98)

0.4003

    

Simple median

1.24 (0.92, 1.67)

0.1514

FinnGen

 

RuminococcaceaeUCG004.id.11362

9

Inverse variance weighted (fixed effects)

0.94 (0.73, 1.22)

0.6549

    

Inverse variance weighted (multiplicative random effects)

0.94 (0.72, 1.23)

0.6687

    

Weighted median

0.79 (0.56, 1.12)

0.1839

    

MR Egger

0.86 (0.21, 3.5)

0.8353

    

Simple median

0.79 (0.55, 1.14)

0.2153

FinnGen

Species

Eubacteriumcoprostanoligenesgroup.id.11375

12

Inverse variance weighted (fixed effects)

0.96 (0.71, 1.30)

0.7951

    

Inverse variance weighted (multiplicative random effects)

0.96 (0.77, 1.19)

0.7138

    

Weighted median

0.86 (0.57, 1.28)

0.4482

    

MR Egger

1.05 (0.25, 4.35)

0.9509

    

Simple median

0.90 (0.61, 1.34)

0.6130

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Journal of Translational Medicine

ISSN: 1479-5876

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