Fig. 1

SCENIC analysis of human adenocarcinoma single cell dataset. A The workflow for this study. B Visualization of the SCENIC regulons from 208,506 cells from GSE131907 by using uniform manifold approximation and projection (UMAP). Each dot represents one cell and is colored according to cell types. C Bubble plot shows specific regulons across cell types. Bubble size is proportional to the percentage of cell types with the binarized AUCell expression, and color intensity is proportional to the scaled AUCell score within a cell type. The motifs of representative regulons are shown. mBrain brain metastases, mLN lymph node metastases, tLung and tL/B, primary tumors in lung or bronchus