Fig. 5

Specificity and safety of Pep42-BBZ CAR-T cells. A Representative images of H&E stained hearts, livers, spleens, lungs, kidneys, and hippocampi sections from both mock-BBZ and Pep42-BBZ CAR-T groups. Two groups of CAR-T cells were injected intravenously into tails veins of tumor-bearing mice (n = 3). After five days, organs were extracted and made into paraffin sections. Scale bars for heart, liver, spleen, lung, and kidney images = 100 μm; scale bar for hippocampi images = 200 μm. B Representative IF staining of livers and lungs with CD3ζ antibodies coupled with Cy3-conjunctated secondary antibodies by IF staining. Scale bars = 100 μm