Fig. 8
From: Targeting RNA-binding protein HuR to inhibit the progression of renal tubular fibrosis
Heatmaps of differential mRNA expression and related pathway dysregulation scores for 760 molecules in the kidney after ischemia–reperfusion (IR) injury analyzed by the NanoString mouse nCounter Fibrosis Panel. a Differential mRNA expression map in IR-injured kidney between untreated (wild type, WT) and KH3-treated wild type mice(KH3) (n = 5/each group) compared to uninjured contralateral kidney (CTL), generated by using the limma software. b Dysregulation score map of 50 annotated profibrotic pathways in those kidneys generated by using nSlover™. c The top 20 upregulated profibrotic pathways and d Five down-regulated cellular energy metabolic pathways induced by IR injury, compared with the pathway scores in uninjured contralateral kidney (CTL) are remarkably ameliorated when KH3 was given