Fig. 5
From: Growth hormone reduces aneuploidy and improves oocytes quality by JAK2-MAPK3/1 pathway in aged mice
Proteomics and bioinformatics analyses of GH + aged compared to aged MII oocytes. A Schematic diagram of the proteomics analysis, and results for GH + aged (blue) and aged (red) MII oocytes (first polar body removed). B Volcano plot of the 118 DE proteins (downregulated, green; upregulated, red) in GH + aged compared to aged oocytes. Highly DE proteins are listed, and 16 proteins related to spindle assembly (triangle) and mitochondria (square) are labelled. C GO enrichment analysis of the 118 DE proteins in GH + aged compared to aged group, performed using Metascape. D KEGG pathway enrichment analysis of the 118 DE proteins in GH + aged compared to aged group, performed using Metascape. The ratio of involved genes to total genes was calculated