Fig. 5
From: Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice
Heat map representation of genes significantly up- or down-regulated by FLU in Jurkat T cells. These genes are associated with the A MAPK pathway, B PI3K-Akt signaling pathway, C pathways in cancer, D JAK-STAT signaling pathway, and E cytokine-cytokine receptor interactions. RNA-seq was performed with total RNA prepared from Jurkat T cells treated with 10 µM FLU for 4 h. Heatmaps were constructed based on z-scores of normalized expression values for the DEG and display expression levels between the biologically-independent samples. Each row is scaled using the scale function of the heat map tool which takes the z-score across each row