Fig. 4
From: Flubendazole inhibits PD-1 and suppresses melanoma growth in immunocompetent mice
FLU modulates gene expression in Jurkat T cells. RNA-seq was performed with total RNA prepared from Jurkat T cells treated with 10 µM FLU for 4 h. A Multidimensional scaling (MDS) analysis. Con1, Con2, Con3 and Treat1, Treat2, Treat3 refer to vehicle and FLU treatment, respectively, where each is a biologically-independent replicate. B Heat map showing the top 100 DEG in our analysis. Heatmap was constructed based on z-scores of normalized expression values for the DEG and display expression levels between the biologically-independent samples. Arrow indicates JUN. C Volcano plot showing representative genes that down-regulated (left) and up-regulated (right) by FLU