Fig. 1

BLM serves as a prognostic biomarker for PCa, and knockdown of BLM has been shown to inhibit cell proliferation and migration in PC3. A Representative images demonstrating BLM expression in PCa tissues and ANT. The scale bars represent 500 μm and 100 μm. B The expression of BLM was higher in 90 PCa tissues compared to ANT. C High expression of BLM was associated with poor DFS in PCa patients. D Transcript levels of BLM in prostate adenocarcinoma (PRAD) as obtained from the TCGA database. E Western blot analysis of BLM in PCa cell lines (LNCaP, 22RV1, PC3, and DU145) and human normal prostate epithelial cells (RWPE-1). F–J Knockdown of BLM inhibited the clonogenicity, vitality, proliferation, invasion, and migration of PC3 cells. Shown are the means ± SD from 3 experiments (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and “ns” indicated no significant difference)