Fig. 9

RP11-296E3.2 is enriched in exosomes and closely correlated with YBX1. A Expression level of RP11-296E3.2 in HCT116 and RKO cells and cell supernatant exosomes (n = 3 per group). B Expression level of RP11-296E3.2 in patient and healthy control serum exosomes. C Expression level of YBX1 in patient and healthy control serum exosomes. The data are presented as the means ± SDs. Statistical significance was assessed using unpaired t test for two comparisons. ****P < 0.0001. D Correlation of the abundances of RP11-296E3.2 and YBX1 in serum exosomes. The correlation between RP11-296E3.2 and YBX1 was using Two-tailed Pearson correlation analysis. E Proposed model in which RP11-296E3.2 mediates CRC cell proliferation and migration of CRC progression