Table 2 Markers with potential predictive value
From: Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Mechanism | Markers |
|---|---|
Direct effects | LKB1 |
Rag GTPases | |
REDD1 | |
mTOR | |
Indirect effects | Blood glucose level |
Insulin/fasting insulin level | |
Insulin resistance | |
Insulin receptors/insulin-like growth factor receptor 1 | |
Targets in the liver (e.g., OCT1/2/3 expression) |