Fig. 4

Butyrate improved ERG visual function in diabetic mice. A Double-beaded arrows reaching toward the dashed lines represent a- and b-waves. B, C The implicit times of the a-wave and b-wave were increased in the T1D group compared with the control group, and this change was reversed in the T1D + NaB group. D, E The changes in a-wave and b-wave amplitudes were not obvious between the T1D and control groups. F Representative results of OPs are shown for the control (black line), T1D (red line), and T1D + NaB (blue line) groups. G, H The OP latency times of the T1D group were significantly increased compared with those of the control group, while these changes were significantly reversed in the T1D + NaB group. I, J There were no differences in OP amplitude between the T1D group and the control group, while OP1 and OP2 significantly increased in the T1D + NaB group compared with the T1D group. The data are expressed as the mean ± SEM (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ERG, Electroretinography