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Table 1 Clinical and demographical characteristics of the study participants

From: Establishment of a potent weighted risk model for determining the progression of diabetic kidney disease

Variables

eGFR(mL/min/1.73m2)

χ 2 /t/W

P-value

Dialysis

χ 2 /t/W

P-value

< 60

≥ 60

Yes

No

(N = 514)

(N = 590)

(N = 288)

(N = 816)

Sex (%)

 Male

358(69.6)

397(67.3)

0.60

0.437

205(71.2)

550(67.4)

1.24

0.266

 Female

156(30.4)

193(32.7)

83(28.8)

266(32.6)

 Age, years (IQR)

66 (16)

63 (18)

135,932

0.003

66 (15)

64 (18)

113,060

0.339

 BMI, kg/m2 (IQR)

24.7 (4.2)

24.6 (4.4)

151,168

0.930

24.5 (4.0)

24.6 (4.4)

123,570

0.192

Stroke (%)

 Yes

122(23.7)

197(33.3)

12.00

0.001

58(20.1)

261(32.0)

13.97

< 0.001

 No

392(76.3)

393(66.7)

230(79.9)

555(68.0)

CHD (%)

 Yes

148(28.8)

125(21.1)

8.14

0.004

86(29.9)

187(22.9)

5.15

0.023

 No

366(71.2)

465(78.9)

202(70.1)

629(77.1)

 Diabetes duration, years (IQR)

15 (10)

11 (12)

113,564

< 0.001

17 (8)

12 (12)

83,238

< 0.001

Smoking status (%)

 Yes

213(41.4)

259(43.9)

0.58

0.446

118(40.9)

354(43.4)

0.41

0.521

 No

301(58.6)

331(56.1)

170(59.1)

462(56.6)

Family history of diabetes (%)

 Yes

165(32.1)

250(42.4)

11.92

< 0.001

81(28.1)

334(40.9)

14.34

< 0.001

 No

349(67.9)

340(57.6)

207(71.9)

482(59.1)

 SBP, mmHg

150.34 ± 23.22

139.31 ± 20.08

−8.39

< 0.001

153.13 ± 22.95

141.38 ± 21.23

−7.62

< 0.001

 DBP, mmHg (IQR)

81 (18)

80 (17)

146,830

0.364

81 (17)

81 (17)

−0.79

0.432

DR (%)

 Yes

356(69.3)

285(48.3)

17.38

< 0.001

193(67.0)

448(54.9)

12.33

< 0.001

 No

158(30.7)

305(51.7)

95(33.0)

368(45.1)

DF (%)

 Yes

29(5.6)

54(9.2)

3.67

0.055

13(4.5)

68(8.3)

4.02

0.045

 No

485(94.4)

536(90.8)

275(95.5)

748(91.7)

 Hemoglobin, g/L (IQR)

94.5 (27)

133 (27)

272,494

< 0.001

91 (24)

125 (33)

198,100

< 0.001

 Neutrophil percentage, % (IQR)

72.6 (11.7)

62.4 (12.7)

76,770

< 0.001

74.3 (10.1)

64.3 (13.5)

60,740

< 0.001

 Serum albumin, g/L (IQR)

31.4 (8.7)

38.9 (6.8)

239,666

< 0.001

31.3 (8.3)

37.2 (8.7)

167,017

< 0.001

 Triglyceride, mmol/L (IQR)

1.5 (1.0)

1.4 (1.2)

153,474

0.727

1.4 (0.9)

1.4 (1.2)

125,516

0.085

 TC, mmol/L (IQR)

4.0 (1.4)

4.0 (1.4)

152,385

0.887

3.8 (1.3)

4.0 (1.4)

125,382

0.090

 Lp(a), mg/L (IQR)

366.5 (398.2)

156.5 (241.8)

88,456

< 0.001

392.5 (388.0)

194.5 (313.0)

76,886

< 0.001

 LDL-C, mmol/L (IQR)

2.2 (1.1)

2.3 (1.1)

158,023

0.226

2.2 (1.1)

2.3 (1.2)

125,017

0.106

 HDL-C, mmol/L (IQR)

0.96 (0.39)

0.92 (0.33)

149,801

0.729

0.92 (0.39)

0.94 (0.34)

125,204

0.098

 SUA, µmol/L (IQR)

386 (149)

317 (119)

98,993

< 0.001

370 (160)

336 (128)

99,506

< 0.001

 HbA1c, % (IQR)

6.5 (1.8)

8.6 (3.1)

237,037

< 0.001

6.3 (1.5)

8.0 (3.0)

180,785

< 0.001

 Plasma fibrinogen, g/L (IQR)

4.4 (1.6)

3.3 (1.4)

76,625

< 0.001

4.4 (1.5)

3.5 (1.7)

78,807

< 0.001

  1. Continuous variables that passed the normality check are expressed as mean ± standard deviation, and t-tests were used to compare the differences between the two groups. Variables which failed to pass the normality check are presented as median (IQR) and the Mann-Whitney U test was performed to compare the differences between the two groups
  2. Significant P values are indicated in Bold
  3. BMI body mass index, CHD coronary heart disease, DBP diastolic blood pressure, DF diabetic foot, DR diabetic retinopathy, eGFR estimated glomerular filtration rate, HbA1c hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, IQR interquartile range, LDL-C low-density lipoprotein cholesterol, Lp(a) lipoprotein(a), SBP systolic blood pressure, SUA serum urea acid, TC total cholesterol
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Journal of Translational Medicine

ISSN: 1479-5876

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