Fig. 7

Effect of RES on target proteins. The mRNA expression levels of ESR1 (B), SLC2A1 (C), AR (E), AKR1B1 (F), IGF1R (H), MMP9 (K), and AKT1 (L) in the HG group are significantly increased, whereas PPARA (A), PPARG (G), and INSR (M) levels are significantly decreased in the HG group compared with the NC group. There are no significant differences in the expression of the SHBG (D), RELA (I), PIK3CA (J), MMP2 (N), and TTR (O) between HG and NC groups. RES treatment is able to reverse the abnormal gene expression of PPARA, SHBG, AKR1B1, PPARG, IGF1R, MMP9, AKT1, and INSR in the HG group. NC: normal control, HG: high glucose, RES: resveratrol, ns: P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001