Table 2 Neonatal microbial signatures and GDM
From: Maternal microbiota and gestational diabetes: impact on infant health
Study/PMID | Location | Sample source | Subject details | Sequencing methodology | Main findings (Microbiota Signatures in GDM) compared to controls |
|---|---|---|---|---|---|
[163] | China | Meconium sample | 418 Mother-infant (147 with GDM and 271 normal pregnant women) | 16S rRNA sequencing (V3 region) |
|
[164] | USA | 2Â weeks infant stool sample | 46 Mother-infant (13 with GDM and 33 normal pregnant women) | 16S rRNA sequencing (V1-V2 region) |
|
[165] | China | Meconium samples | 120 Mother-infants (60 with GDM and 60 normal pregnant women) | 16S rRNA sequencing (V3 region) |
|
[166] | Brazil | Meconium samples | 84 Obese mothers with infants (40 with GDM and 44 normal pregnant women) | 16S rRNA gene sequencing (V4 region | No significant difference in diversity or taxonomy was observed |
[14] | China | Meconium samples | 83 Infant meconium samples from GDM and non GDM mothers | 16S rRNA gene sequencing (V3-V4) |
|
Alpha diversity
Proteobacteria
Firmicutes
Lactobacillus
Flavonifractor
Erysipelotrichaceae
Phascolarctobacterium
Alpha and beta diversity
Enhydrobacter, Psychrobacter, Aerococcus, Faecalibacterium, Herbaspirillum, Pelomonas, Burkholderia-Caballeronia-Paraburkholderia
Xanthobacter, Cytophaga, Serratia, and Actinomyces
Enterobacter, Hydrogenophilus, Weissella
Corynebacterium, Escherichia, Enhydrobacter, Bacteroides, Brevundimonas, Paracoccus, Schiegelella, Enterococcus
Decrease in relative abundance
Increase in relative abundance
Decrease in relative abundance
Increase in relative abundance