Fig. 5

Negative correlation between plasma ECE1 level and retinal thickness. A The column charts indicate the value of WBC, NEUT, NLR, LMR, PDW, MPV, and P-LCR in five groups. B Chord diagram showing the relationships between clinical parameters and proteins in sEVs, lEVs, and plasma by Pearson correlation analysis. Only correlations with absolute values of correlation coefficients greater than 0.5 and p < 0.05 are displayed. C Linear fit was applied to the scatterplot in the discovery and validation cohorts. The Pearson correlation coefficient (r) and p-value (p) are displayed on each graph. D Boxplots showing the average thickness values of OCT and concentrations of ECE1 in plasma in the validation cohort. WBC white blood cells, NEUT neutrophil, NLR neutrophil-to-lymphocyte ratio, LMR lymphocyte to monocyte ratio, PDW platelet distribution width, MPV mean platelet volume, P-LCR platelet-large cell rate, AS ankylosing spondylitis-related acute anterior uveitis, BD Behcet's disease uveitis, SCL posterior scleritis, VKH Vogt-Koyanagi-Harada syndrome, HC healthy control, OCT-ave average retinal thickness on the optical coherence tomography scan, abbreviations of clinical parameters are listed in Additional file 10: Table S5