Fig. 1

Proteomic analysis reveals specific proteomic profiles in EVs and plasma. A Workflow for acquiring proteomic data. B Venn diagram showing the overlap between the EVs protein database from Vesiclepedia and the identified proteins in our EVs samples. C Venn diagram showing the overlap between the exosomal proteins from the ExoCarta databases and the identified proteins in our sEVs samples. D Scatter plot displays the distribution of the number of quantifiable proteins detected per sample. E Bar plots showing GO terms in the cellular component category enriched by proteins specifically identified in sEVs and lEVs. F Principal component analysis score plots based on the 2,387 shared proteins in the three components. AS ankylosing spondylitis-related acute anterior uveitis, BD Behcet's disease uveitis, SCL posterior scleritis, VKH Vogt-Koyanagi-Harada syndrome, HC healthy control, SWATH-MS sequential window acquisition of all theoretical fragment ions-mass spectrometry